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270 In PASMCs from PH rats, the Wnt/-catenin pathway is activated, allowing -catenin to enter the nucleus and interact with TCF4

Adipose tissue function and expandability as determinants of lipotoxicity and the metabolic syndrome

Disclosures: Faris Shweikeh: Nothing to Disclose, Rajshri Joshi: Nothing to Disclose, Margaret McGuigan: Nothing to Disclose, Anjali Nidhaan: Nothing to Disclose, Amandeep Singh: Nothing to Disclose 1769 NATIONAL HEPATITIS PROFILES: A GLOBAL HCV REPORT Jana Manning 1 John Ward 2 Lindsey Hiebert 3 , 1 Task Force for Global Health- Coalition for Global Hepatitis, 2 Viral Hepatitis Action Coalition, 3 The Task Force for Global Health - Coalition for Global Hepatitis Elimination Background: To reach elimination goals for HCV incidence and related deaths, countries must develop strategic information, plans, and policies to prevent, detect, and treat HCV